Abstract: Animal experiments based on animal models are necessary means in basic medical research, drug development and evaluation of medical devices, and play a very important role in the development of medicine and even modern science and technology. In recent years, the continuous development of animal experiments has brought many new challenges. More attention should be paid to the welfare of experimental animals in biomedical research than ever before. This paper aims to strengthen the depth control of pain management and animal welfare of basic medical postgraduates and other animal experiment practitioners while ensuring the experimental result. Through the comparative analysis of animal models of diseases involved in new coronavirus research and tumor research, the important position of pain management in animal welfare is highlighted. The related contents of animal welfare and pain management in the construction of common medical experimental animal models in China at the present stage are summarized and suggestions are put forward.

Key words: animal model, animal welfare, pain management

摘要： 以构建动物模型为基础的动物实验是在基础医学研究、药物研发、医疗器械的评价中必须采取的手段,对医学甚至现代科技的发展起着十分重要的作用。 近年来,动物实验的不断发展带来了许多新的挑战,在生物医学研究中比以往任何时候都需要更加关注实验动物的福利。 本文旨在加强基础医学研究生以及其他动物实验从业人员在确保实验结果的同时对疼痛管理及动物福利的深度把控。 通过对新冠病毒研究和肿瘤研究中所涉及的疾病动物模型方法进行对比分析,重点突出疼痛管理问题在动物福利中的重要地位,总结了现阶段我国常见的医学实验动物模型构建中动物福利及疼痛管理的相关内容并提出建议。

关键词: 动物模型, 动物福利, 疼痛管理